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. 2016 Sep 1;7(40):66020–66031. doi: 10.18632/oncotarget.11791

Figure 2. Dynamics of somatic mutations in ctDNA.

Figure 2

Fluctuations in allele fraction of somatic mutations (right Y axis) generally correlated with tumor burden reflected by imaging method (left Y axis), with increased allele fraction concurring with or even preluding disease progression (panel A., patient No.3; panel B., patient No.17).