Table 5. Association between SP110 and PMP22 tSNPs and TB risk based on different inheritance models.
SNP_ID | Model | Genotype | Case | Control | OR | 95%CI | p value |
---|---|---|---|---|---|---|---|
rs6436917 | Dominant | G-G/G-A | 161 | 265 | 1.30 | 0.88,1.94 | 0.1656 |
A-A | 55 | 118 | |||||
Recessive | G-G | 61 | 76 | 1.59 | 1.06,2.39 | 0.0188* | |
G-A/A-A | 155 | 307 | |||||
rs4327230 | Dominant | G-G/G-C | 32 | 132 | 0.33 | 0.27,0.51 | 0.0001* |
C-C | 185 | 251 | |||||
Recessive | G-G | 2 | 12 | 0.29 | 0.03,1.31 | 0.0847 | |
G-C/C-C | 215 | 371 | |||||
rs2114591 | Dominant | C-C/C-T | 78 | 192 | 0.56 | 0.393,0.80 | 0.0008* |
T-T | 139 | 191 | |||||
Recessive | C-C | 10 | 39 | 0.43 | 0.19,0.89 | 0.0166* | |
C-T/T-T | 207 | 344 | |||||
rs7580912 | Dominant | C-C/C-T | 139 | 243 | 1.03 | 0.72,1.48 | 0.8816 |
T-T | 78 | 140 | |||||
Recessive | C-C | 34 | 54 | 1.13 | 0.69,1.84 | 0.6017 | |
C-T/T-T | 183 | 329 | |||||
rs13422 | Dominant | A-A/A-C | 152 | 228 | 1.57 | 1.08,2.28 | 0.0127* |
C-C | 65 | 153 | |||||
Recessive | A-A | 42 | 45 | 1.79 | 1.10,2.91 | 0.0119* | |
A-C/C-C | 175 | 336 | |||||
rs230915 | Dominant | G-G/G-C | 101 | 191 | 0.88 | 0.62,1.25 | 0.4676 |
C-C | 112 | 187 | |||||
Recessive | G-G | 13 | 35 | 0.64 | 0.30,1.27 | 0.1775 | |
G-C/C-C | 200 | 343 | |||||
rs231024 | Dominant | A-A/A-G | 106 | 216 | 0.74 | 0.52,1.05 | 0.0748 |
G-G | 111 | 167 | |||||
Recessive | A-A | 16 | 38 | 0.73 | 0.37,1.37 | 0.2946 | |
A-G/G-G | 201 | 345 |
OR: odd ratio; CI: confidence interval.
*p≤0.05.
Bonferroni's multiple adjustment was applied, with p 0.00178 (0.05/28).