Figure 2. BCR-ABL/NF-κB crosstalk.

Numerous pathways, including Ras, MEKK1, c-Jun N-terminal kinase (JNK) and protein kinase D2 (PKD2) are activated by the Bcr-Abl and converge on NF-κB activation. NF-κB activation is also under the regulation of osteopontin or CUEDC2, as indicated.