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. Author manuscript; available in PMC: 2017 Feb 23.
Published in final edited form as: Biol Psychiatry. 2011 Aug 6;70(10):954–961. doi: 10.1016/j.biopsych.2011.06.022

Table 2.

Functional MRI results

Brain areas Side X Y Z Z score P value
a. All stimuli types (irrespective of the light and prosody conditions)
SAD > Controls
Thalamus 1 R 14 −18 4 3.61 0.010
Brainstem 1 L −2 −28 −22 3.58 0.011
Controls > SAD
No significant voxel
b. Anger prosody stimuli
[Blue > dark] × [SAD > Controls]
Hypothalamus 2, 4 L −2 −2 −12 3.21 0.027
[Blue > dark] × [Controls > SAD]
No significant voxel
[Green > dark] × [SAD > Controls]
No significant voxel
[Green > dark] × [Controls > SAD]
Hypothalamus 3, 4 L −4 −2 −18 3.13 0.032

XYZ: relative coordinates (mm) in MNI space.

1

The same two significant clusters of voxel are obtained in the thalamus and brainstem if the analyses only included 1) all stimuli in darkness; 2) all stimuli under green light exposure; 3) all stimuli under blue light exposure; 4) emotional stimuli under blue or green light exposure ; 5) neutral stimuli in under blue or green light exposure (i.e. theses differences between groups are observed for every stimuli subgroups).

2

Clusters not affected by an exclusive mask (p=0.05) of the (Neutral × [Blue > dark] × [SAD > Controls]) contrast, indicating that the light condition effect was specific to the emotional (angry prosody) stimuli.

3

Clusters not affected by an exclusive mask (p=0.05) of the (Neutral × [Green > dark] × [SAD > Controls]) contrast, indicating that the light condition effect was specific to the emotional (angry prosody) stimuli.

4

Because of the difference in irradiance level between blue and green light (see technical issue in the methods section) the contrast computing the interaction between blue and green light conditions [(Blue > Green)] × [SAD > Controls] is not valid. However, if this contrast is nevertheless computed, it shows a single significant difference in the hypothalamus (−2 0 −18 mm; Z = 3.73; psvc = 0.006) which further strengthens the results obtained for each light condition separately.