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. Author manuscript; available in PMC: 2017 Aug 6.
Published in final edited form as: Nat Neurosci. 2017 Feb 6;20(3):484–496. doi: 10.1038/nn.4495

Figure 8. DEPICT predicts specific neuronal subtypes affecting BMI.

Figure 8

(A) DEPICT predicts transcripts from BMI-associated loci (p < 3×10−3), but not WHR, DM2, or anorexia-linked loci, are enriched in neurons. The dotted line shows statistically significant enrichment. (B) DEPICT predicts transcripts from BMI-associated loci (P < 1×10−2) are enriched in n25.Trh/Lef1 and n32.Slc17a6/Trhr neuron clusters. (C) Heatmap of n25.Trh/Lef1 and n32.Slc17a6/Trhr neuron cluster expression of genes near BMI-linked loci or related to obesity susceptibility.