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. Author manuscript; available in PMC: 2017 May 14.
Published in final edited form as: Oncogene. 2016 Nov 14;36(8):1080–1089. doi: 10.1038/onc.2016.272

Figure 6. Y-27632 inhibits tumor growth in vivo.

Figure 6

(a) 5 × 106 786-OT1 cells were injected into the right flank of 18 NOG mice. After one month, mice were randomized into two groups. Mice were treated daily with PBS vehicle (n = 9) or 10 mg/kg Y-27632 (n = 9) by ip injection. The fold change in tumor volume was analyzed statistically using a One-way ANOVA with treatment as the factor (*p < 0.05, **p < 0.01, ***p < 0.005), SEMs are shown. The solid line represents the linear trend fit of the data for each treatment group. (b) Representative images of a control mouse (top) and a Y-27632-treated mouse (bottom) on day 14 of treatment are shown.