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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Dec 29;37(3):466–475. doi: 10.1161/ATVBAHA.116.308749

Figure 2. Adipocyte-specific deficiency of NOX4 improves the insulin sensitivity before 16 weeks, but not after 24 weeks on a HFHS diet during the development of obesity.

Figure 2

Adipoq-Cre/+;NOX4+/+ and Adipoq-Cre/+;NOX4Flox/Flox mice were fed a HFHS diet for the indicated time periods (n=6). A; Deletion of NOX4 in the adipocyte-enriched fraction from epididymal adipose tissue by Adipoq-Cre. The AE and SVC fractions from epididymal adipose tissues of Adipoq-Cre/+;NOX4+/+ and Adipoq-Cre/+;NOX4Flox/Flox mice were isolated and analyzed by Western blotting using a NOX4 antibody. Data are representative of at least 3 independent experiments (n=2). B and C; Body weight (B), GTT and ITT (C) were measured at the indicated time points. *P < 0.01 vs. Adipoq-Cre/+;NOX4+/+ in HFHS. ANOVA and Bonferroni post-hoc test.