Table 2.
Expression of TREM-1, TREM-2 and TREM-1/TREM-2 ratio in subjects with obesity compared to controls.
| TREM1 and TREM2 expression in subjects with obesity (22) |
SO+D− (7) | SO+D+ (15) | Correlation (R); P value |
||
|---|---|---|---|---|---|
| TREM1 (over- expression) |
Liver | 19 (86.4%) | 4 (57.14%) | 15 (100%)* | R=0.582; P=0.023 |
| Omentum | 21 (95.45%) | 6 (85.71%) | 15 (100%) | NS | |
| Subcutaneous | 16 (72.72%) | 4 (57.14%) | 12 (80%) | NS | |
| Serum | 19 (95.45%) | 4 (57.14%) | 15 (100%)* | R=0.582; P=0.023 | |
| TREM2 (under- expression) |
Liver | 17 (77.27%) | 4 (57.14%) | 13 (86.66%) | |
| Omentum | 21 (95.45%) | 6 (85.71%) | 15 (100%) | ||
| Subcutaneous | 15 (68.18%) | 3 (42.85%) | 12 (80%) | NS | |
| Serum | 20 (90.90%) | 5 (71.4%) | 15 (100%) | ||
| TREM1/ TREM2 ratio |
Liver | 19 (86.4%) | 4 (57.14%) | 15 (100%)* | R=0.582; P=0.023 |
| Omentum | 21 (95.45) | 6 (85.7%) | 15 (100%) | NS | |
| Subcutaneous | 16 (72.72%) | 4 (57.1%) | 12 (80%) | NS | |
| Serum | 19 (95.45%) | 4 (57.14%) | 15 (100%)* | R=0.582; P=0.023 | |
Higher number of subjects with overexpression of TREM-1, down regulation of TREM-2 and TREM-1/TREM-2 ratio were analyzed between SO+D− and SO+D+ using Fisher’s exact test or Pearson’s χ2 for categorical variables. Increased in folds of TREM-1 or TREM-2 expressions were regarded as over expression, likewise decrease in folds as under-expression. To describe the balance between pro and anti-inflammatory state, we analyzed TREM-1/TREM-2 ratio in all the study subjects. Data show number of subjects having higher values of these compared to controls (SO−D−). Values show number of subjects (% subjects of total), not significant (NS). Abbreviations: SO−D− = subjects without obesity and diabetes; SO+D− = subjects with obesity but not diabetes; SO+D+ = subjects with obesity and diabetes.
p<0.05.