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The ratio of urine AUC to serum AUC indicates the decreased renal clearance rate for G6 dendrimers, compared with G4 dendrimers.
| G6 dendrimer | G4 dendrimer | |
|---|---|---|
| Time of HCA | 1.5 hrs | 2.0 hrs |
| Administration method | 1st dose: 10% bolus dose at 3 hr before HCA conclusion; 2nd dose: 70% i.v. infusion 0-6 hrs after HCA; 3rd dose: 20% bolus dose at 24 hrs after HCA. | A single dose of 1 hr i.v. infusion after HCA |
| Dose | 6 mg/kg | 5 mg/kg |
| Urine AUC/ Serum AUC | 0.57 | 3.77 |
