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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Biosens Bioelectron. 2016 Dec 30;91:588–605. doi: 10.1016/j.bios.2016.12.062

Figure 9.

Figure 9

Application of nanopore gated electrical sensor combined with optical detection in a microfluidic platform. (A) Schematic view on particle movement through the nanopore gate. Liquid flow direction shown with blue arrow. Red area demonstrates the optical excitation volume. (B) Movement of biological particle through electrically gated nanopore. (C) Two characteristic signals, electrical (black) and optical fluorescence (red), for separate detection events related to a single particle. The electrical current dip and the fluorescence spike appear separated due to time need for a particle to travel (flow) from the nanopore towards the optical excitation spot (Δt). (D) Computational cross-correlation of detection events (particles), adjusted for delay time (Δt). Adapted with permission from ref (Liu 2014). Copyright 2014, ACS.