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. Author manuscript; available in PMC: 2018 Feb 22.
Published in final edited form as: Cell Syst. 2017 Jan 26;4(2):231–241.e11. doi: 10.1016/j.cels.2016.12.003

Figure 4.

Figure 4

A: four regions of “sneaking through”, and B: no sneaking-through when eliminating suppressor T cells, plots drawn from data in (Gatenby, Basten, and Creswick 1981). Very low zone (less than 100 cells): low tumor incidence; low zone (102 – 103 cells): tolerance of tumor; moderate zone (103 – 105 cells): immunogenic (low tumor); high zone (> 106): again tolerogenic. C: Another illustration of the same general idea of four regions. Plot drawn from data in (Kolsch and Mengersen 1976). The x axis in these plots case measures the initial number of tumor cells, and not the rate of growth λ of tumor as it did as in Figure 3. In both cases, the y-axis measures the percentages of mice in which tumors were detected by some predetermined point. Supplemental Section G discusses experiments in more detail.