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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 Jan 12;37(3):433–445. doi: 10.1161/ATVBAHA.116.307787

Figure 1.

Figure 1

Angiogenesis and vasodilation was restored in Sprague Dawley (SD) rats undergoing high salt diet (4% NaCl) suppression of the renin-angiotensin system. (A) Rats were unilaterally stimulated while intravenously treated with AngII, Ang-(1-7) or vehicle (V), and co-treated with AT1R antagonist (Losartan) or Mas1 antagonist (A779). Both AngII through the AT1 receptor and Ang-(1-7) through the MAS1 receptor significantly restored angiogenesis versus vehicle (*p<0.05). (B) Maximum change of isolated rat middle cerebral artery diameter in response to acetylcholine (Ach; 10−5 M) following AngII, Ang-(1-7) or vehicle co-treatment with Losartan and A779 was measured. Both AngII acting through AT1R and Ang-(1-7) acting through the Mas1 receptor restored the vasodilation response to acetylcholine (Ach; *p<0.05; N is indicated above for each condition).