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. 2017 Feb 24;10:41. doi: 10.3389/fnmol.2017.00041

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Copyright © 2017 Hegle, Frank, Berndt, Klose, Allan and Accili.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ih disruption compromises adult motility in Drosophila melanogaster. (A) Photographs of wild type, Ih^IE/Ih^RB and Ih^RB/Ih^RB adult flies aged 15 days. Hypomorphic flies exhibit compromised posture and are hyper-excitable compared to wild type, including spontaneous leg tremors (arrowheads) and seizure-like episodes. (B) Graph of adult climbing ability over time for a series of Ih alleles, using a negative geotaxis assay. Groups of 8–10 flies were tested for their ability to climb 4 cm in 8 s. The percentage of flies reaching 4 cm (the climbing index) was averaged among 4 trials for each group. 4–6 vials per genotype were assessed every 5 days. Climbing index was observed to decrease significantly over time in Ih hypomorphic mutants compared to wild type using one-way ANOVA with Dunnet's multiple comparisons test. (^**p < 0.001 by day 5, ^***p < 0.0001 by day 17).