. 2017 Feb 21;23(7):1147–1162. doi: 10.3748/wjg.v23.i7.1147

Table 3.

In vitro kinetics of prodrugs in aqueous buffers, gastrointestinal tract homogenates and fecal matter

Prodrug	Incubation medium
	HCl buffer (pH 1.2) and stomach homogenates	Phosphate buffer (pH 7.4) and intestinal homogenates	Colon homogenate				Fecal matter
	HCl buffer (pH 1.2) and stomach homogenates	Phosphate buffer (pH 7.4) and intestinal homogenates	K ± SD (min^-1)¹	t_1/2 (min)	Prodrug hydrolyzed	BBA released	K ± SD (min^-1)¹	t_1/2 (min)	Prodrug hydrolyzed	BBA released
BH	Stable	Negligible	0.0013	514.1	78.10%	73.60%	0.0009	723.1	62.29%	57.37%
BH	Stable	hydrolysis	0.0013	514.1	78.10%	73.60%	0.0009	723.1	62.29%	57.37%
BP	Stable	Negligible	0.0014	488.3	75.08%	71.79%	0.0010	636.7	57.38%	56.67%
BP	Stable	hydrolysis	0.0014	488.3	75.08%	71.79%	0.0010	636.7	57.38%	56.67%
BT	Stable	Negligible	0.0018	379.4	86.67%	86.39%	0.0010	662.5	69.75%	72.52%
BT	Stable	hydrolysis	0.0018	379.4	86.67%	86.39%	0.0010	662.5	69.75%	72.52%
BTY	Stable	Negligible	0.0014	484.4	70.33%	68.57%	0.0010	677.6	55.95%	55.13%
BTY	Stable	hydrolysis	0.0014	484.4	70.33%	68.57%	0.0010	677.6	55.95%	55.13%

Average of three readings; follows first-order kinetics.