Fig. 4.

Fundus photographs (left column), optical coherence tomography images (center column), and indocyanine green angiography (ICGA, right column) images of a 60-year-old man with polypoidal choroidal vasculopathy (PCV) treated with a fixed-dosing regimen of aflibercept (three initial monthly injections followed by bimonthly injections). a–c At baseline, subretinal fluid (SRF) and a pigment epithelial detachment (PED) related to PCV are apparent. Visual acuity was 20/40. A branching vascular network and polypoidal vessels are visible on ICGA. d–f At 3 months, SRF had resolved even though polypoidal lesions had only partially regressed. g, h New SRF is visible 6 (arrow). I, j A subretinal hemorrhage and a large PED are noted. k–m Although SRF had resolved, visual acuity had decreased to 20/125 and new polypoidal lesions developed, as visible on ICGA (arrows)