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. 2017 Feb 14;174(6):438–453. doi: 10.1111/bph.13709

Figure 2.

Figure 2

The effect of cAMP analogues on RPP of rat isolated Langendorff‐perfused hearts. The data are presented as percentage of pretreatment values calculated for each heart. Panel A – Changes in RPP induced by heart perfusion with 8‐Br (5 μM) alone or in the presence of 1 μM ESI‐09 or 10 μM H‐89. Groups of hearts: 8‐Br, n = 7; 8‐Br + ESI‐09, n = 7; 8‐Br + H‐89, n = 6. *P < 0.05, significant effect of inhibitor (H‐89 or ESI‐09). Panel B – Changes of RPP induced by heart perfusion with 8‐Br (10 μM) alone or in the presence of 3 μM PKI. Groups of hearts: 8‐Br, n = 7; PKI, n = 5; 8‐Br + PKI, n = 5. Panel C – Changes of RPP induced by the heart perfusion with 6‐Bnz (10 μM) and CPT (10 μM) alone or in combination. Groups of hearts: 6‐Bnz, n = 5; CPT, n = 5; 6‐Bnz + CPT, n = 6. *P < 0.05, significantly different from the combination of 6‐Bnz and CPT.