. 2017 Feb 14;174(6):438–453. doi: 10.1111/bph.13709

Table 1.

Effects of 8‐Br with or without ESI‐09 (inhibitor of Epac), H‐89 or PKI (inhibitors of PKA) and chelerythrine (Chel; inhibitor of PKC) on haemodynamic function recovery during reperfusion

Parameters	LVDP (mmHg)	HR (beat·min⁻¹)	RPP (mmHg·beat·min⁻¹)·10³	+dP·dt⁻¹ (mmHg·s⁻¹)·10²	−dP·dt⁻¹(mmHg·s⁻¹)·10²
Pre‐ischaemic equilibration (n = 58)	64.8 ± 2.4	294.3 ± 5.4	19.1 ± 0.8	28.4 ± 1.1	−20.3 ± 1.0
Reperfusion
Experimental Series 1
Control (n = 7)	19.0 ± 4.0***	289.0 ± 21.8	5.5 ± 1.0***	9.9 ± 1.1***	−9.6 ± 1.0***
8−Br (5 μM, n = 7)	64.5 ± 7.6*	262.7 ± 10.5	17.3 ± 2.6*	23.2 ± 3.1*	−16.0 ± 2.3*
8−Br + ESI−09 (n = 7)	23.3 ± 8.0**	231.1 ± 13.0*	5.4 ± 1.9**	8.7 ± 2.2**	−7.9 ± 1.6**
8−Br + H−89 (n = 6)	26.1 ± 4.9 *	202.8 ± 25.5*	5.0 ± 1.3**	10.0 ± 1.6**	−8.5 ± 1.2**
ESI−09 (n = 7)	19.2 ± 4.0 *	264 ± 10.8	5.1 ± 1.1 *	8.7 ± 1.4 *	−8.8 ± 1.4 *
Experimental series 2
Control (n = 7)	32.5 ± 6.7***	300.4 ± 5.5	8.6 ± 1.3***	13.7 ± 2.6***	−12.2 ± 2.4***
8−Br (10 μM, n = 7)	97.4 ± 9.1* ***	245.4 ± 11.6*	23.7 ± 2.7*	34.2 ± 3.8*	−23.9 ± 2.3*
8−Br + Chel (n = 5)	102.9 ± 7.4*	228.2 ± 14.9*	23.4 ± 2.1*	39.6 ± 3.2*	−26.9 ± 2.4*
8−Br + PKI (n = 5)	57.8 ± 7.1*	294.0 ± 11.4	17.1 ± 2.4*	24.4 ± 3.4*	−20.2 ± 2.4*
PKI (n = 5)	37.2 ± 9.2 *	294.2 ± 37.9	7.5 ± 2.6 *	15.4 ± 4.0 *	−14.4 ± 3.2***

Haemodynamic function was recorded throughout the experimental protocol. The data shown are for the end of the equilibration period prior to ischaemia and after 60 min reperfusion. Pre‐ischaemic data are shown as average of all the hearts of this series of experiments.

P < 0.05 significantly different from control;

^**

P < 0.05 significantly different from 8‐Br of the corresponding experimental series;

^***

P < 0.05 significantly different from initial (end of equilibration) value of the same group of hearts.