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a) Synthetic route of cyclooctyne modified siRNA. b) PAGE gel verification of successful modification of siRNA. Lane 1: free siRNA; Lane 2: cyclooctyne modified siRNA. c) Agarose gel electrophoresis assay for the release of siRNA by acid induced hydrolysis. Lane 2: cyclooctyne modified siRNA duplex; Lane 3: PNSDS; Lane 4: acid hydrolysis of PNSDS. d) SEM image of PNSDS. Scale bar is 1 μm. e) Particle size of PNSDS. f) The hydrolysis of AAPEG at pH 7.4 and 5.0.
