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. 2016 Oct 5;21(3):543–551. doi: 10.1111/jcmm.13000

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© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Morphological and expression profile changes of cultures of MDA‐MB‐231 breast carcinoma cells in the presence of a patient's serum with a high level of autoantibodies against carbonic anhydrase I and with an aplastic anemia‐like syndrome. (A) A light‐microscope image of living cells with changed morphology cultivated in patient's serum (SK) on day 7 compared to cells cultivated in a medium containing foetal serum (FS) negative for anti‐CA I autoantibodies, magnification 100×. (B) Statistically significantly downregulated genes associated for example with adhesion, cytoskeleton and a proto‐oncogene WNT7B; RNA microarray map.