Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of KATP regulation of ECFC proliferation, migration and angiogenesis. Opening KATP leads to the influx of Ca2+ in ECFCs, as a result of K+ efflux. The increase of Ca2+ up‐regulates CaMKII activation. Furthermore, P‐CaMKII leads to a high phosphorylated level of Akt and eNOS. Meanwhile, P‐Akt induces activation of eNOS in ECFCs. Ca2+/Akt/eNOS pathway exhibits an effect on improving ECFC proliferation, migration and angiogenesis.
