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. 2017 Jan 12;6(3):267–275. doi: 10.1016/j.molmet.2017.01.002

Figure 4.

Figure 4

Overexpression of adiponectin receptors, but not acid ceramidase, rescues glucose homeostasis in ob/ob mice. A) Ceramide species of the indicated chain lengths were quantified in mesenteric and inguinal adipose depots from ob/ob mice following 2 weeks of dox-induced overexpression to drive Art-AdipoR2 or Art-Acid Ceramidase (AC). Data were quantified and expressed as % of wildtype ob/ob control. B) Circulating glucose levels were measured during an oral glucose tolerance test (OGTT) (2.5 g/kg glucose per oral gavage) in ob/ob, ob/ob Art-AC, and ob/ob Art-AdipoR2 transgenic mice C) Circulating glucose levels were measured during an oral glucose tolerance test (OGTT) (2.5 g/kg glucose per oral gavage) after 10 days of dox-induced expression of AdipoR2 or Acid Ceramidase in the liver of ob/ob mice (* depicts ob/ob vs ob/obAlb-R2, # depicts ob/ob vs ob/obAlb-AC). D) Insulin levels before and during the OGTT were measured by ELISA. E) Total ceramide levels were quantified in livers from ob/ob mice following 2 h of AdipoRon or PBS control treatment. *,#P < 0.05 by Student's t test.