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. 2017 Feb 1;6(3):233–235. doi: 10.1016/j.molmet.2017.01.011

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Adiponectin is secreted into the blood stream from adipose tissue. It binds to its receptors AdipoR1 and AdiopoR2 in liver and adipose tissue. Both tissues can be induced to over-express those receptors. Over-expressing AdipoR1 and AdiopR2 leads to an increased number of ligand–receptor interactions which then leads to elevated ceramidase activity. This results in an increase in cellular S1P abundance and a decrease in cellular ceramide abundance. In animals that over-express AdipoR1 and AdiopoR2 glucose tolerance is improved as well as whole body insulin sensitivity.