Figure 3.

Electron microscopy of skin from Eurasier dog with epidermolysis bullosa simplex. (a) Eurasier puppy with separation in the basement membrane zone. Note the electron-dense hemidesmosomes (arrowheads) as compared with hemidesmosome in an aged matched control dog (b). Bar = 2 µm. (c) At higher magnification the hemidesmosomes are cone shaped (arrowheads) with loss of distinction between inner and outer plaques. (d) Normal hemidesmosomes from an age-matched control dog showing distinct inner and outer plaques (arrowheads). Bar = 0.5 µm