Skip to main content
. 2017 Feb 24;7:43290. doi: 10.1038/srep43290

Figure 6. Preparation of Subset A derivatives: introduction of C25 linear and C26/C27 branched aliphatic side chains on hyodeoxycholane scaffold.

Figure 6

Reagents and conditions: (a) n-BuLi, isopropyl triphenylphosponium iodide, THF dry, r.t., 84%; (b) HCl 37%, MeOH, quantitative yield; (c) H2, Pd(OH)2 degussa type, THF:MeOH dry 1:1, quantitative yield; (d) n-BuLi, isobutyl triphenylphosponium iodide, THF dry, r.t.; (e) HCl 37%, MeOH; (f) H2, Pd(OH)2 degussa type, THF:MeOH dry 1:1; (g) n-BuLi, methyl triphenylphosponium iodide, THF dry, r.t, 60%; (h) HCl 37%, MeOH, quantitative yield; (i) H2, Pd(OH)2 degussa type, THF:MeOH dry 1:1, 70%.