Table 2. EC₅₀ values for selected compounds.

	GPBAR1	LXRα
Compound	Affinity (μM)*	Affinity (μM)
Selective LXRα agonists
4		6.99 ± 0.31
5		8.2 ± 0.16
8		2.7 ± 0.65
9		5.1 ± 0.43
12		12.4 ± 0.41
GPBAR1/LXRα dual agonists
13	4.2 ± 0.79	22.3 ± 3.05
14	4.9 ± 0.2	3.2 ± 0.03
Selective GPBAR1 agonists
15	3.7 ± 0.38
17	2.54 ± 0.015
20	6.8 ± 0.08
21	5.9 ± 0.055
24	0.91 ± 0.092
25	7.6 ± 0.71
27	1 ± 0.062
29	4.9 ± 0.06
30	1.98 ± 0.145

^*Data are mean ± SE of 3 experiments in duplicate.