Table 1. Association between the 21 selected previously reported SNPs and risk of CRC in the study population.

SNP	Chr	Position	Mapped Gene	Risk Allele	Risk Allele Frequency	Reported p-value	Reported OR	OR MCC-Spain	95% CI	p-value
rs10752881	1	183004356	KRT18P28 - LAMC1	A	0.76	5.0E-06	1.07	1.11	1.01–1.21	0.04
rs6691170	1	221872104	DUSP10 - QRSL1P2	T	0.31	1.0E-09	1.06	1.09	0.99–1.20	0.08
rs10936599	3	169774313	MYNN	C	0.19	3.0E-08	1.04	1.10	0.98–1.23	0.11
rs1321311	6	36655123	N/A	C	0.30	1.0E-10	1.10	1.03	0.93–1.15	0.54
rs7758229	6	160419220	SLC22A3	T	0.67	8.0E-09	1.28	1.07	0.96–1.18	0.21
rs16892766	8	116618444	LINC00536 - EIF3H	C	0.39	3.0E-18	1.27	1.17	0.98–1.39	0.08
rs6983267	8	127401060	CCAT2 - LOC101930033	G	0.82	1.0E-14	1.27	1.10	1.00–1.21	0.04
rs10795668	10	8659256	RNA5SP299 - LINC00709	G	0.73	5.0E-15	1.15	1.06	0.95–1.17	0.30
rs4948317	10	58811675	BICC1	C	0.30	7.0E-08	1.10	1.07	0.97–1.18	0.19
rs3802842	11	111300984	COLCA2 - COLCA1	C	0.08	6.0E-10	1.11	1.09	0.98–1.20	0.12
rs3824999	11	74634505	POLD3	G	0.13	4.0E-10	1.08	1.09	1.00–1.20	0.06
rs10879357	12	72020783	TPH2	G	0.50	3.0E-06	1.25	1.00	0.91–1.11	0.94
rs11169552	12	50761880	DIP2B - ATF1	C	0.82	2.0E-10	1.09	1.02	0.91–1.14	0.80
rs7315438	12	115453598	TBX3 - UBA52P7	T	0.41	6.0E-06	1.11	1.03	0.94–1.13	0.53
rs4444235	14	53944201	RPS3AP46 - MIR5580	C	0.43	8.0E-10	1.11	1.03	0.94–1.13	0.51
rs9929218	16	68787043	CDH1	G	0.46	1.0E-08	1.10	1.13	1.01–1.25	0.03
rs4939827	18	48927093	SMAD7	T	0.27	8.0E-28	1.20	1.22	1.11–1.34	0.03
rs10411210	19	33041394	RHPN2	C	0.31	5.0E-09	1.15	1.01	0.88–1.16	0.92
rs4925386	20	62345988	LAMA5	C	0.58	2.0E-10	1.08	1.08	0.98–1.19	0.14
rs961253	20	6423634	FGFR3P3 - CASC20	A	0.28	2.0E-10	1.12	1.10	1.00–1.22	0.05
rs5934683	X	9783434	GPR143 - SHROOM2	C	0.57	7.0E-10	1.07	1.04	0.93–1.17	0.46

SNPs associated with CRC risk in MCC population with p < 0.05 are highlighted in bold.