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Left, in the absence of PBP3, lipid II is loaded into the pore of FtsW and translocated but cannot be released. Right, Interaction of PBP3 with FtsW induces conformational changes in the loop between TM 7 and 8, opening the pore gate and allowing the release of lipid II. The loop between TMs 9 and 10 is required for the localisation of PBP3 at the septum.
