Table 2.

SOFA derivatives used as endpoints

SOFA derivative	Description	Included RCTs
Fixed-day SOFA	SOFA score on a fixed day after randomization	58a
Early fixed-day SOFA	SOFA score on days 2, 3, 4 or 5 after randomization	55a
Late fixed-day SOFA	SOFA score on days 7, 10 or 14 after randomization	32a
Delta SOFA	Trajectory of SOFA score from baseline	25
Delta fixed-day SOFA	SOFA score on a fixed day after randomization minus baseline SOFA score	18
Delta maximum SOFA	Maximum SOFA score during ICU stay minus baseline SOFA score	7
Other SOFA derivatives
Maximum SOFA	Maximum SOFA score during ICU stay	9
Mean SOFA	Mean SOFA score during ICU stay	3
Discharge SOFA	SOFA score at ICU discharge or death	3

^aTwenty-nine trials reported both early and late SOFA scores. SOFA sequential organ failure assessment