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. 2017 Feb 23;36:35. doi: 10.1186/s13046-017-0502-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Cinchonine inhibited tumor growth and induced apoptosis in nude mice. a The growth ratio of the control group (2.839 ± 0.583) was greater than experiment I (2.266 ± 0.467) and experiment II (1.324 ± 0.367 P < 0.05). b The control group, which was treated with no cinchonine, showed nearly no TUNEL positive cells. In experimental group-I and group-II, showed more TUNEL positive cells when treated with cinchonine. The result demonstrates that cinchonine can induce apoptosis and the quantity of apoptosis is dose-dependent