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. 2017 Feb 23;18:40. doi: 10.1186/s12931-017-0522-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Immunohistochemistry of M1 and M2 alveolar macrophages in lung tissue. M1 (iNOS⁺) and M2 (CD206⁺) expression in clusters of alveolar macrophages in consecutive lung sections from a patient with severe COPD (panels a and c) and from a non-smoker (panels b and d). iNOS immunoreactivity appears as a brown diffuse cytoplasmic granular pattern (panel a), while CD206 immunoreactivity appears as a red linear pattern around the cellular membrane (panel c). In the smoker with severe COPD both M1 (iNOS⁺) (panel a) and M2 (CD206⁺) (panel c) immunoreactivity was present in the same cluster of alveolar macrophages. The alveolar macrophages in the non-smoking subject (panels B and D) were mostly negative for either stains. Immunostaining with anti-iNOS (in brown) and anti-CD206 (in red). Original magnification: X 400