Table 2.
Baseline data of patients with chronic thromboembolic pulmonary hypertension before acute vasoreactivity testing
| Factors | Negative group (n = 150) | Positive group (n = 25) | Statistics | P |
|---|---|---|---|---|
| Gender (n) | ||||
| Female | 57 | 10 | 0.036† | 0.820 |
| Male | 93 | 15 | ||
| Age (years) | 56.75 ± 11.89 | 58.36 ± 10.31 | 0.636‡ | 0.520 |
| Body mass index (kg/m2) | 24.43 ± 3.73 | 26.17 ± 4.55* | 2.047‡ | 0.040 |
| WHO-FC (n) | ||||
| I–II | 72 | 16 | 2.194† | 0.130 |
| III–IV | 78 | 9 | ||
| 6MWD (m) | 330.13 ± 101.04 | 347.65 ± 150.77 | 0.534‡ | 0.600 |
| NT-proBNP (ng/L) | 1690.00 (2702.80) | 569.25 (1011.39)* | −3.712§ | <0.010 |
| mBP (mmHg) | 91.66 ± 13.34 | 97.04 ± 16.11 | 1.762‡ | 0.070 |
| mPAP (mmHg) | 52.02 ± 11.31 | 46.52 ± 10.15* | −2.285‡ | 0.020 |
| PVR (dyn·s−1·m−5) | 1163.81 ± 513.96 | 738.12 ± 234.03* | −6.731‡ | <0.010 |
| VR (dyn·s−1·m−5) | 2097.00 (981.50) | 1742.00 (667.00)* | −2.347§ | 0.020 |
| CO (L/min) | 3.28 ± 1.01 | 4.06 ± 0.85* | 3.530‡ | <0.010 |
| SaO2 (%) | 91.55 (5.03) | 91.00 (4.55) | −0.017§ | 0.970 |
| SvO2 (%) | 62.00 ± 12.12 | 68.16 ± 8.05* | 3.274‡ | <0.010 |
| PaO2 (mmHg) | 64.31 ± 12.80 | 61.18 ± 12.65 | −0.706‡ | 0.300 |
| PvO2 (mmHg) | 35.80 (9.80) | 39.80 (13.95)* | −3.652§ | <0.010 |
| Qs/Qt (%) | 23.83 ± 9.93 | 25.72 ± 8.98 | 0.745‡ | 0.490 |
Data are presented as mean ± SD or median (interquartile range). *Means the data in positive group versus that in negative group, P<0.05; †χ2 value; ‡t value; §Z value. The independent-sample t-test was used to analyze the date of normal distribution. The rank sum test of two independent samples (Mann-Whitney U-test) was used to analyze the date of nonnormal distribution. Categorical data on gender and WHO-FC were expressed as number of cases and analyzed using the Chi-square test. 6MWD: 6-min walking distance; CO: Cardiac output; mBP: Mean blood pressure; mPAP: Mean pulmonary arterial pressure; NT-proBNP: N-terminal pro-brain natriuretic peptide; PaO2: Partial pressure of oxygen in arterial blood; PvO2: Mixed venous oxygen partial pressure; PVR: Pulmonary vascular resistance; Qs/Qt: Intrapulmonary shunt; SaO2: Arterial oxygen saturation; SvO2: Mixed venous oxygen saturation; SVR: Systemic vascular resistance; WHO-FC: World Health Organization functional class; SD: Standard deviation. 1 mmHg = 0.133 kPa.