[Table/Fig-6]:
Relationship between immunohistochemical expression of ALDH1 and clinicopathologic factors in the studied colorectal carcinoma.
| Variables | Expression of ALDH1 | Test of significance | p-value | |
|---|---|---|---|---|
| Positive | Negative | |||
| Age | ||||
| Mean±SD | 50.51±12.41 | 62.17.±13.7 | u=96.5 | 0.003** |
| ≤ 45 | 12(85.7%) | 2(14.3%) | FE=1.11 | 0.45 |
| > 45 | 25(71.4%) | 10(28.6%) | ||
| Sex | ||||
| Male | 15(78.9%) | 4(21.1%) | FE=1.98 | 0.74 |
| Female | 22(73.3%) | 8(26.7%) | ||
| Size | ||||
| Mean±SD | 6.43±3.44 | 4.75±1.73 | u=171.5 | 0.24 |
| ≤ 5 | 18(66.7%) | 9(33.3%) | χ2=2.54 | 0.11 |
| > 5 | 19(86.4%) | 3(13.6%) | ||
| Site | ||||
| Left | 15(62.5%) | 9(37.5%) | χ2=4.31 | 0.03* |
| Right | 22(88%) | 3(12%) | ||
| Gross | ||||
| Fungating | 23(88.5%) | 3(11.5%) | χ2=5.09 | 0.08 |
| Ulcerating | 12(60%) | 8(40%) | ||
| Annular | 2(66.7%) | 1(33.3%) | ||
| Type | ||||
| Adenocarcinoma | 29(72.5%) | 11(27.5%) | FE=1.07 | 0.42 |
| Mucoid carcinoma | 8(88.9%) | 1(11.1%) | ||
| Grade | ||||
| I | 1(100%) | 0(0%) | χ2=1.49 | 0.48 |
| II | 28(71.8%) | 11(28.2%) | ||
| III | 8(88.9%) | 1(11.1%) | ||
| Vascular invasion | ||||
| Present | 6(85.7%) | 1(14.3%) | FE=0.46 | 0.67 |
| Absent | 31(73.8%) | 11(26.2%) | ||
| Necrosis | ||||
| Present | 16(66.7%) | 8(33.3%) | χ2=1.99 | 0.19 |
| Absent | 21(84%) | 4(16%) | ||
| Perineural invasion | ||||
| Present | 6(85.7%) | 1(14.3%) | FE=0.46 | 0.67 |
| Absent | 31(73.8%) | 11(26.2%) | ||
| Lymph node invasion | ||||
| Present | 19(90.5%) | 2(9.5%) | χ2=4.45 | 0.03* |
| Absent | 18(64.3%) | 10(35.7%) | ||
| N0 | 18(64.3%) | 10(35.7%) | χ2=4.51 | 0.10 |
| N1 | 12(92.3%) | 1(7.7%) | ||
| N2 | 7(87.5%) | 1(12.5%) | ||
| Stage | ||||
| T1 | 1(100%) | 0(0%) | χ2=1.56 | 0.67 |
| T2 | 7(63.6%) | 4(36.4%) | ||
| T3 | 19(76%) | 6(24%) | ||
| T4 | 10(83.3%) | 2(16.7%) | ||
| Modified Dukes stage | ||||
| A | 1(100%) | 0(0%) | χ2=3.54 | 0.47 |
| B1 | 3(75%) | 1(25%) | ||
| B2 | 14(63.6%) | 8(36.4%) | ||
| C1 | 9(90%) | 1(10%) | ||
| C2 | 10(83.3%) | 2(16.7%) | ||
| Mitotic count | ||||
| Mean±SD | 8.68±4.56 | 8.1±4.23 | U=201.5 | 0.63 |
| Apoptotic | ||||
| Mean±SD | 3.29±2.61 | 4.05.±3.54. | U=186.5 | 0.41 |
SD: standerd deviation FE: Fisher’s Exact χ2=Chi-Squares U= Mann-Whitney *=significance **= highly significance