Table 1.
Demographics and baseline characteristics (FAS)
| 300 IR (n = 315) | 500 IR (n = 296) | Placebo (n = 316) | ||
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| Age (years) | Mean ± SD | 30.0 ± 11.8 | 30.5 ± 11.7 | 30.2 ± 11.6 |
| 12≤ to <18 | 57 (18.1) | 55 (18.6) | 59 (18.7) | |
| 18≤ to <51 | 245 (77.8) | 228 (77.0) | 245 (77.5) | |
| 51≤ to <65 | 13 (4.1) | 13 (4.4) | 12 (3.8) | |
| Gender | Male | 145 (46.0) | 126 (42.6) | 137 (43.4) |
| Female | 170 (54.0) | 170 (57.4) | 179 (56.6) | |
| Rescue medication use during pretreatment period | Yes | 23 (7.3) | 18 (6.1) | 23 (7.3) |
| No | 292 (92.7) | 278 (93.9) | 293 (92.7) | |
| Duration of perennial allergic rhinitis | <5 years | 19 (6.0) | 20 (6.8) | 20 (6.3) |
| 5≤ to <10 years | 75 (23.8) | 66 (22.3) | 62 (19.6) | |
| 10 years ≤ | 221 (70.2) | 210 (70.9) | 234 (74.1) | |
| Serum‐specific IgE level to Dermatophagoides pteronyssinus (Ua/ml) | <0.35 | 0 | 0 | 1 (0.3) |
| 0.35≤ to <0.70 | 0 | 1 (0.3) | 1 (0.3) | |
| 0.70≤ to <3.5 | 51 (16.2) | 48 (16.2) | 42 (13.3) | |
| 3.5≤ to <17.5 | 102 (32.4) | 107 (36.1) | 125 (39.6) | |
| 17.5≤ to <50 | 91 (28.9) | 77 (26.0) | 79 (25.0) | |
| 50≤ to <100 | 45 (14.3) | 42 (14.2) | 51 (16.1) | |
| 100≤ | 26 (8.3) | 21 (7.1) | 17 (5.4) | |
| Serum‐specific IgE level to D. farinae (Ua/ml) | <0.35 | 0 | 0 | 1 (0.3) |
| 0.35≤ to <0.70 | 5 (1.6) | 2 (0.7) | 0 | |
| 0.70≤ to <3.5 | 38 (12.1) | 43 (14.5) | 37 (11.7) | |
| 3.5≤ to <17.5 | 105 (33.3) | 97 (32.8) | 110 (34.8) | |
| 17.5≤ to <50 | 86 (27.3) | 89 (30.1) | 98 (31.0) | |
| 50≤ to <100 | 57 (18.1) | 38 (12.8) | 54 (17.1) | |
| 100≤ | 24 (7.6) | 27 (9.1) | 16 (5.1) | |
| Sensitization status | Monosensitizeda | 99 (31.4) | 88 (29.7) | 98 (31.0) |
| Polysensitizedb | 216 (68.6) | 208 (70.3) | 218 (69.0) | |
| Average Rhinitis Total Symptom Score at baseline | Mean ± SD | 9.05 ± 2.03 | 9.00 ± 1.93 | 9.06 ± 2.01 |
| <10 | 220 (69.8) | 208 (70.3) | 220 (69.6) | |
| 10≤ to <13 | 79 (25.1) | 75 (25.3) | 80 (25.3) | |
| 13≤ | 16 (5.1) | 13 (4.4) | 16 (5.1) | |
a
No sensitization other than D. pteronyssinus or D. farinae among the tested allergens (level of serum‐specific IgE against all other allergens less than 0.70 Ua/ml).
b
At least one sensitization in addition to D. pteronyssinus or D. farinae (level of serum‐specific IgE against any other allergen is 0.70 Ua/ml or higher).