Table 4.
Results From the Regression Models Assessing the Relationship Between Atrophy Rates (Outcome Measures) and log2WMH Volume, CSF Aβ, and tau (Predictors)
| Controls | MCI | AD | |
|---|---|---|---|
| N | 100 | 167 | 86 |
| Rate of whole‐brain atrophy (ml/yr) | 6.25 (5.64 to 6.86); p < 0.001 | 11.46 (10.53 to 12.40); p < 0.001 | 14.48 (13.18 to 15.79); p < 0.001 |
| Rate of hippocampal atrophy (ml/yr) | 0.06 (0.05 to 0.07); p < 0.001 | 0.15 (0.14 to 0.16); p < 0.001 | 0.19 (0.17 to 0.21); p < 0.001 |
| Association between WMH and whole‐brain atrophy ratea | 0.3 (0.07 to 0.6); p = 0.01 | 0.2 (−0.2 to 0.6); p = 0.4 | −0.2 (−0.8 to 0.3); p = 0.4 |
| Association between WMH and hippocampal atrophy ratea | 0.008 (0.004 to 0.01); p < 0.001 | 0.004 (−0.002 to 0.01); p = 0.2 | −0.0008 (−0.008 to 0.007); p = 0.8 |
| Association between CSF Aβ42 and whole‐brain atrophy rateb | −0.2 (−0.3 to −0.06); p = 0.004 | −0.4 (−0.6 to −0.2); p < 0.001 | −0.3 (−0.6 to 0.03); p = 0.08 |
| Association between CSF Aβ42 and hippocampal atrophy rateb | −0.001 (−0.003 to 0.0008); p = 0.2 | −0.006 (−0.009 to −0.003); p < 0.001 | −0.004 (−0.008 to 0.0003); p = 0.07 |
| Association between CSF tau and whole‐brain atrophy ratec | 0.2 (−0.04 to 0.4); p = 0.1 | 0.04 (−0.2 to 0.2); p = 0.7 | 0.1 (−0.1 to 0.3); p = 0.4 |
| Association between CSF tau and hippocampal atrophy ratec | 0.005 (0.002 to 0.009); p = 0.006 | 0.002 (−0.001 to 0.005); p = 0.3 | −0.001 (−0.004 to 0.002); p = 0.6 |
| Association between WMH and whole‐brain atrophy rate adjusted for hippocampal atrophy rated | 0.1 (−0.1 to 0.3); p = 0.4 | −0.004 (−0.3 to 0.3); p > 0.9 | −0.2 (−0.7 to 0.3); p = 0.5 |
| Association between WMH and hippocampal atrophy rate adjusted for whole‐brain atrophy ratee | 0.005 (0.001 to 0.009); p = 0.007 | 0.002 (−0.002 to 0.007); p = 0.4 | −0.0004 (−0.007 to 0.007); p = 0.9 |
Estimates are shown with 95% confidence intervals for increase in atrophy rate in ml/year: for a doubling of WMH conditional on intracranial volume, CSF Aβ42 and tau.
Estimates are shown with 95% confidence intervals for increase in atrophy rate in ml/year: for a 10 pg/ml increase in Aβ conditional on intracranial volume, log2WMH volume and CSF tau.
Estimates are shown with 95% confidence intervals for increase in atrophy rate in ml/year: for a 10 pg/ml increase in tau, conditional on intracranial volume, Aβ42 and log2WMH volume.
Estimates are shown with 95% confidence intervals for increase in atrophy rate in ml/year: for a doubling of WMH conditional on intracranial volume, CSF Aβ42 and tau, hippocampal atrophy rate.
Estimates are shown with 95% confidence intervals for increase in atrophy rate in ml/year: for a whole‐brain atrophy rate.