Table 3.
Mean (CV) Plasma Pharmacokinetic Parameters of Delafloxacin by Hepatic Function Group
| Parameter | Group A Mild (n = 6) | Group D Match (n = 6) | Group B Moderate (n = 6) | Group D Match (n = 6) | Group C Severe (n = 6) | Group D Match (n = 6) | Group D Overall (n = 18) |
|---|---|---|---|---|---|---|---|
| AUC0‐∞ (μg · h/mL) | 23.5 (16.3) | 21.7 (17.3)a | 23.4 (9.2) | 23.6 (19.9) | 24.4 (28.7) | 17.2 (15.2) | 20.8 (21.9)b |
| Cmax (μg/mL) | 9.2 (15.5) | 9.3 (17.3) | 7.9 (9.8) | 9.0 (19.9) | 8.4 (30.6) | 8.3 (21.3) | 8.9 (18.9) |
| t½ (hours) | 13.5 (58.7) | 8.2 (62.5)a | 9.1 (92.5) | 9.3 (50.9) | 5.3 (24.4) | 7.1 (80.1) | 8.2 (60.4)b |
| CL (L/h) | 13.1 (17.9) | 14.1 (14.3)a | 12.9 (9.1) | 13.2 (22.7) | 13.6 (41.3) | 17.9 (17.4) | 15.1 (22.3)b |
| Vss (L) | 50.9 (20.2) | 44.8 (18.6)a | 48.7 (20.2) | 51.5 (25.3) | 49.7 (42.5) | 47.9 (23.5) | 48.3 (22.5)b |
a
n = 5.
b
n = 17.