Table 4.
Statistical Analysis of the Effect of Food on Plasma Pharmacokinetic Parameters of Omadacycline (N = 31)
| Parameter | Treatment | Geometric LS Mean | Treatment Comparison | Ratio of Geometric LS Mean (%) | 90%CI of Ratio (%) |
|---|---|---|---|---|---|
| AUC0‐24, μg·h/mL | A | 7.4 | |||
| B | 6.2 | B/A | 83.4 | 74.9, 92.7 | |
| C | 4.3 | C/A | 57.7 | 51.9, 64.2 | |
| D | 2.8 | D/A | 37.3 | 33.6, 41.5 | |
| AUC0‐t, μg·h/mL | A | 7.4 | |||
| B | 6.2 | B/A | 83.3 | 74.9, 92.7 | |
| C | 4.3 | C/A | 57.7 | 51.9, 64.1 | |
| D | 2.8 | D/A | 37.3 | 33.5, 41.4 | |
| AUC0‐∞, μg·h/mL | Aa | 10.6 | |||
| B | 9.0 | B/A | 84.7 | 75.8, 94.6 | |
| C | 6.2 | C/A | 58.4 | 52.3, 65.3 | |
| D | 4.0 | D/A | 37.9 | 34.0, 42.3 | |
| Cmax, μg/L | A | 0.66 | |||
| B | 0.56 | B/A | 84.5 | 75.9, 94.1 | |
| C | 0.39 | C/A | 60.1 | 54.0, 66.9 | |
| D | 0.27 | D/A | 40.7 | 36.5, 45.2 |
CI, confidence interval; LS, least squares.
a
N = 30, a terminal monoexponential phase could not be identified for 1 participant.