Table 2.
Associations between the six most significantly associated TRPA1 SNPs in ALSPAC and current doctor‐diagnosed asthma at 7–8 years in ALSPAC and PIAMA, and current doctor‐diagnosed asthma at 6 years in Generation R
| SNP | Alleles | ALSPAC | PIAMA | GENERATION R | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | OR | p‐value | N | OR | p‐value | N | OR | p‐value | ||
| rs959974a | G/G | 1401 | 1.00 | 512 | 1.00 | 555 | 1.00 | |||
| G/T | 2615 | 1.33 (1.07–1.65) | 0.009 | 932 | 1.36 (0.77–2.38) | 0.28 | 1054 | 1.15 (0.61, 2.14) | 0.67 | |
| T/T | 1125 | 1.69 (1.32–2.16) | 0.00001 | 433 | 1.82 (0.99–3.36) | 0.053 | 464 | 1.39 (0.68, 2.82) | 0.37 | |
| Per allele | 1.30 (1.15–1.47) | 0.00001 | 1.35 (1.00–1.83) | 0.052 | 1.18 (0.83, 1.68) | 0.37 | ||||
| rs1384001b | C/C | 1400 | 1.00 | 512 | 1.00 | 555 | 1.00 | |||
| A/C | 2616 | 1.33 (1.07–1.65) | 0.009 | 933 | 1.36 (0.78–2.38) | 0.28 | 1054 | 1.15 (0.61, 2.14) | 0.67 | |
| A/A | 1125 | 1.69 (1.32–2.15) | 0.00001 | 432 | 1.83 (0.99–3.37) | 0.053 | 464 | 1.39 (0.68, 2.82) | 0.37 | |
| Per allele | 1.30 (1.15–1.47) | 0.00001 | 1.35 (1.00–1.83) | 0.051 | 1.18 (0.83, 1.68) | 0.37 | ||||
| rs4738202a | A/A | 483 | 1.00 | 150 | 1.00 | 179 | 1.00 | |||
| A/G | 2233 | 1.45 (1.02–2.05) | 0.038 | 816 | 1.54 (0.54–4.41) | 0.42 | 880 | 0.71 (0.30, 1.68) | 0.44 | |
| G/G | 2425 | 1.66 (1.18–2.34) | 0.004 | 911 | 2.21 (0.79–6.20) | 0.13 | 1,014 | 0.78 (0.34, 1.81) | 0.57 | |
| Per allele | 1.22 (1.07–1.39) | 0.004 | 1.45 (1.01–2.09) | 0.042 | 0.96 (0.65, 1.41) | 0.83 | ||||
| rs7010969b | A/A | 827 | 1.00 | 299 | 1.00 | 324 | 1.00 | |||
| A/C | 2477 | 1.43 (1.09–1.89) | 0.010 | 920 | 1.09 (0.56–2.10) | 0.80 | 1005 | 1.08 (0.51, 2.32) | 0.84 | |
| C/C | 1837 | 1.74 (1.31–2.29) | 0.00005 | 658 | 1.42 (0.73–2.77) | 0.30 | 744 | 1.20 (0.55, 2.62) | 0.65 | |
| Per allele | 1.28 (1.13–1.46 | 0.00004 | 1.23 (0.89–1.68) | 0.21 | 1.10 (0.76, 1.59) | 0.61 | ||||
| rs3735945b | C/C | 4067 | 1.00 | 1519 | 1.00 | 1621 | 1.00 | |||
| C/T | 1005 | 1.38 (1.13–1.68) | 0.002 | 338 | 1.15 (0.67–1.95) | 0.61 | 428 | 1.40 (0.80, 2.47) | 0.24 | |
| T/T | 69 | 1.19 (0.59–2.41) | 0.633 | 20 | 0.00 (0.00 to –)c | 0.99 | 24 | 0.00 (0.00 to –)c | 0.99 | |
| Per allele | 1.30 (1.09–1.55) | 0.003 | 1.01 (0.61–1.65) | 0.98 | 1.21 (0.71, 2.04) | 0.48 | ||||
| rs920829d | C/C | 4066 | 1.00 | 1519 | 1.00 | 1621 | 1.00 | |||
| C/T | 1001 | 1.37 (1.12–1.68) | 0.002 | 338 | 1.15 (0.67–1.95) | 0.61 | 428 | 1.40 (0.80, 2.47) | 0.24 | |
| T/T | 69 | 1.19 (059–2.41) | 0.634 | 20 | 0.00 (0.00 to –)c | 0.99 | 24 | 0.00 (0.00 to –)c | 0.99 | |
| Per allele | 1.30 (1.09–1.54) | 0.004 | 1.01 (0.61–1.65) | 0.98 | 1.21 (0.71, 2.04) | 0.48 | ||||
a
Genotyped in ALSPAC and in PIAMA, and imputed in Generation R.
b
Genotyped in ALSPAC, and imputed in PIAMA and Generation R.
c
No asthma cases in minor allele homozygote group in PIAMA and Generation R.
d
Imputed in ALSPAC and in PIAMA, and genotyped in Generation R.