Table 3.

Per‐allele associations between the six most significantly associated TRPA1 SNPs and current doctor‐diagnosed asthma, stratified by prenatal paracetamol exposure during early and late gestation in ALSPAC

SNP	N	Paracetamol early in pregnancy OR (95% C.I.)	p‐value	N	Paracetamol later in pregnancy OR (95% C.I.)	p‐value
rs959974
Exposed	2734	1.29 (1.10–1.50)	0.002	2118	1.26 (1.06–1.50)	0.008
Unexposed	2338	1.37 (1.12–1.66)	0.002	2889	1.31 (1.10–1.56)	0.002
		p‐interaction	0.639		p‐interaction	0.765
rs1384001
Exposed	2734	1.29 (1.10–1.50)	0.002	2118	1.26 (1.06–1.50)	0.008
Unexposed	2338	1.37 (1.12–1.66)	0.002	2889	1.31 (1.10–1.56)	0.002
		p‐interaction	0.643		p‐interaction	0.760
rs4738202
Exposed	2734	1.22 (1.03–1.45)	0.024	2118	1.23 (1.02–1.49)	0.031
Unexposed	2338	1.24 (1.00–1.54)	0.049	2889	1.18 (0.97–1.43)	0.090
		p‐interaction	0.910		p‐interaction	0.753
rs7010969
Exposed	2734	1.25 (1.07–1.47)	0.006	2118	1.25 (1.05–1.50)	0.012
Unexposed	2338	1.34 (1.09–1.64)	0.005	2889	1.31 (1.09–1.57)	0.003
		p‐interaction	0.621		p‐interaction	0.738
rs3735945
Exposed	2734	1.15 (0.91–1.44)	0.242	2118	1.31 (1.02–1.68)	0.036
Unexposed	2338	1.59 (1.20–2.09)	0.001	2889	1.24 (0.96–1.60)	0.096
		p‐interaction	0.076		p‐interaction	0.755
rs920829
Exposed	2732	1.15 (0.91–1.44)	0.238	2114	1.30 (1.01–1.67)	0.041
Unexposed	2335	1.57 (1.19–2.08)	0.001	2888	1.24 (0.96–1.61)	0.093
		p‐interaction	0.086		p‐interaction	0.809