Table 4.

Per‐allele associations between the three most significantly associated TRPA1 SNPs and total IgE concentration, stratified by prenatal paracetamol exposure during early and late gestation in ALSPAC

SNP	N	Paracetamol early in pregnancy GMRa (95% C.I.)	p‐value	N	Paracetamol later in pregnancy GMRa (95% C.I.)	p‐value
rs959974
Exposed	2066	1.12 (1.01–1.24)	0.037	1587	1.22 (1.08–1.37)	0.001
Unexposed	1719	1.05 (0.94–1.17)	0.408	2149	1.01 (0.91–1.12)	0.849
		p‐interaction	0.414		p‐interaction	0.017
rs1384001
Exposed	2066	1.12 (1.01–1.24)	0.037	1587	1.22 (1.08–1.37)	0.001
Unexposed	1719	1.05 (0.94–1.17)	0.402	2149	1.01 (0.91–1.12)	0.849
		p‐interaction	0.418		p‐interaction	0.016
rs4738202
Exposed	2066	1.16 (1.03–1.29)	0.011	1587	1.21 (1.06–1.37)	0.003
Unexposed	1719	1.02 (0.91–1.15)	0.714	2149	1.03 (0.92–1.15)	0.585
		p‐interaction	0.145		p‐interaction	0.062

^aGeometric Mean Ratio.