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. 2016 Dec 27;45(1):175–191. doi: 10.1111/ejn.13476

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© 2016 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The PREDIGT score quantifies the probability for the risk (PR) of Parkinson disease (PD) as a function of five factors: E (Exposome); D (Genetics); I (Initiation); G (Sex/Gender); and T (Time). The disease projection curve for a case of idiopathic PD is shown (solid line), where a PR of 100% is reached at 66 years of age. The curve shifts based on values for the five factors, thus changing the incidence risk at a given age, for example, to a PR = 80% at 52 years, 70% at 72 years and 60% at 88 years.