Figure 8.

Validation of the segmented regression models for each metabolite at 2000 L bioreactor scale. The specific production rates of each metabolites for three 2000 L bioreactors runs with the same experimental condition are presented as a function of time (day) as the specific growth rate profiles are similar. The error bars correspond to 3 standard deviations. The prediction model (red line) is based on the segmented regression of the calibration dataset (Fig. 6) and is based on the experimental specific growth rate profile (Fig. 5b). The prediction variability is due to the growth rate value variability and the error bars presented for the prediction correspond also to the three standard deviation. When the prediction was out of the 3 standard deviations range, the corresponding day is crossed in red.