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. 2016 Nov 21;114(4):785–797. doi: 10.1002/bit.26214

Table I.

Segmented model coefficients. For each metabolites and for each metabolic phase, the value of coefficient a and b from equation (5) is presented

a (10−09 mmol/cell) b (10−09 mmol/cell.day)
P1 P2 P3 P1 P2 P3
NH4+ 12.45 (9.90) 0.16 (−0.18) 7.81 (−6.10) 0.04 (0.04)
Gly 2.04 (2.12) 0.002 (0.08) 1.07 (−1.15) 0.02 (0.02)
Ala 5.15 (4.78) 0.11 (0.02) 3.03 (−2.84) 0.02 (−0.02)
Pro 0.05 (−0.10) 0.06 (−0.04)
Val 0.06 (−0.13) 0.09 (−0.06)
Leu 0.09 (−0.14) 0.12 (−0.08)
Ile 0.07 (−0.03) 0.06 (−0.04)
Met 0.46 (−0.57) 0.03 (−0.006) 0.24 (N/A) 0.28 (0.36) 0.01 (0.0044) 0.04 (N/A)
Phe 0.04 (−0.05) 0.03 (−0.02)
Tyr −0.00009 (−0.05) 0.06 (−0.03)
Trp 0.009 (−0.012) 0.02 (−0.01)
Ser 1.47 (−1.87) 0.08 (−0.17) 0.48 (0.14) 0.18 (−0.14)
Thr 0.04 (−0.09) 0.07 (−0.05)
Cys 0.01 (−0.06) 0.07 (−0.05)
Asn 0.44 (−0.49) 0.78 (N/A) 0.25 (−0.17) 0.11 (N/A)
Gln 12.39 (−12.17) −0.03 (−0.06) 7.42 (7.38) 0.007 (0.007)
Lys 0.10 (−0.20) 0.10 (−0.06)
His 0.03 (−0.05) 0.01 (−0.009)
Arg 3.14 (−0.72) 0.08 (−0.09) 2.19 (0.38) 0.03 (−0.03)
Asp 1.97 (1.49) 0.02 (−0.02) 1.25 (−0.95) 0.05 (−0.05)
Glu 1.84 (1.31) 0.07 (0.05) 1.20 (N/A) 1.19 (−0.85) 0.09 (−0.09) 0.18 (N/A)
Glc 18.34 (−18.58) 0.04 (−0.21) 9.61 (10.00) 0.98 (−0.88)
Lac 63.41 (56.79) 0.05 (0.15) 17.66 (N/A) 39.42 (−35.51) 0.03 (−0.06) 4.86 (N/A)
mAb 0.0006 (−0.0002) 0.0007 (0.006)

The coefficients were also identified with the cross validation dataset and presented in the brackets. Red names correspond to metabolites that are impacted by the three metabolic phases. Bold names are metabolites that are impacted by two metabolic phases. Glc − glucose; Lac − lactate, mAb − monoclonal antibody.