Table I.
a (10−09 mmol/cell) | b (10−09 mmol/cell.day) | |||||
---|---|---|---|---|---|---|
P1 | P2 | P3 | P1 | P2 | P3 | |
NH4+ | 12.45 (9.90) | −0.16 (−0.18) | −7.81 (−6.10) | 0.04 (0.04) | ||
Gly | 2.04 (2.12) | −0.002 (0.08) | −1.07 (−1.15) | 0.02 (0.02) | ||
Ala | 5.15 (4.78) | −0.11 (0.02) | −3.03 (−2.84) | 0.02 (−0.02) | ||
Pro | −0.05 (−0.10) | −0.06 (−0.04) | ||||
Val | −0.06 (−0.13) | −0.09 (−0.06) | ||||
Leu | −0.09 (−0.14) | −0.12 (−0.08) | ||||
Ile | −0.07 (−0.03) | −0.06 (−0.04) | ||||
Met | −0.46 (−0.57) | −0.03 (−0.006) | −0.24 (N/A) | 0.28 (0.36) | 0.01 (0.0044) | −0.04 (N/A) |
Phe | −0.04 (−0.05) | −0.03 (−0.02) | ||||
Tyr | −0.00009 (−0.05) | −0.06 (−0.03) | ||||
Trp | −0.009 (−0.012) | −0.02 (−0.01) | ||||
Ser | −1.47 (−1.87) | −0.08 (−0.17) | 0.48 (0.14) | −0.18 (−0.14) | ||
Thr | −0.04 (−0.09) | −0.07 (−0.05) | ||||
Cys | 0.01 (−0.06) | −0.07 (−0.05) | ||||
Asn | −0.44 (−0.49) | 0.78 (N/A) | −0.25 (−0.17) | −0.11 (N/A) | ||
Gln | −12.39 (−12.17) | −0.03 (−0.06) | 7.42 (7.38) | 0.007 (0.007) | ||
Lys | −0.10 (−0.20) | −0.10 (−0.06) | ||||
His | −0.03 (−0.05) | −0.01 (−0.009) | ||||
Arg | −3.14 (−0.72) | −0.08 (−0.09) | 2.19 (0.38) | −0.03 (−0.03) | ||
Asp | 1.97 (1.49) | −0.02 (−0.02) | −1.25 (−0.95) | −0.05 (−0.05) | ||
Glu | 1.84 (1.31) | 0.07 (0.05) | 1.20 (N/A) | −1.19 (−0.85) | −0.09 (−0.09) | 0.18 (N/A) |
Glc | −18.34 (−18.58) | −0.04 (−0.21) | 9.61 (10.00) | −0.98 (−0.88) | ||
Lac | 63.41 (56.79) | −0.05 (0.15) | −17.66 (N/A) | −39.42 (−35.51) | 0.03 (−0.06) | −4.86 (N/A) |
mAb | −0.0006 (−0.0002) | 0.0007 (0.006) |
The coefficients were also identified with the cross validation dataset and presented in the brackets. Red names correspond to metabolites that are impacted by the three metabolic phases. Bold names are metabolites that are impacted by two metabolic phases. Glc − glucose; Lac − lactate, mAb − monoclonal antibody.