Figure 3.

Transient increase in IFN‐γ expression by splenic T‐cells from PD‐1 antibody‐treated mice bearing premalignant oral lesions. Mice bearing 4NQO‐induced premalignant oral lesions were treated with either isotype control or PD‐1 antibodies. After 1, 3 and 5 weeks of treatment, sample mice were sacrificed and their spleens were immunostained extracellularly for CD4 and CD8, and intracellularly for IFN‐γ. Shown are percentages of positive‐staining cells from groups of 5 mice per group per each time point (mean ± SD).