Table 1.

Family 16 methyltransferases in yeast and human

Name	Organism	Substrate and site	Methylation degree	UniProt accession	Ref(s)
Efm2	Yeast	eEF2‐K613	Di	P38347	19, 20
Efm3	Yeast	eEF2‐K509	Tri	P47163	20, 21, 22
Efm6	Yeast	eEF1A‐K390	Mono	P53970	23
Efm7	Yeast	eEF1A‐G2/K3	Tri/Di	Q05874	24
Rkm5	Yeast	RPL1A/B‐K47	Mono	Q12367	25
Hpm1	Yeast	RPL3‐H243	Mono	P40481	26
VCP‐KMT	Human	VCP‐K315	Tri	Q9H867	28, 29
HSPA‐KMT	Human	Hsp70s: HSPA1‐K561, HSPA5‐K585, HSPA8‐K561	Tri	Q8WXB1	29, 30
METTL22	Human	KIN17‐K135	Tri	Q9BUU2	29, 31
eEF2‐KMT	Human	eEF2‐K525	Tri	Q96G04	21
CaM‐KMT	Human	Calmodulin‐K116	Tri	Q7Z624	27
ETFB‐KMT	Human	ETFB‐K200/K203	Tri/Tri	Q8IXQ9	32, 33
METTL18	Human	–	–	O95568	–
METTL21B	Human	–	–	Q96AZ1	–
METTL21C	Human	–	–	Q5VZV1	–
METTL23	Human	–	–	Q86XA0	–