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. 2017 Feb;23(2):220–231. doi: 10.3201/eid2302.161072

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This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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Glycan array analysis of influenza A virus mutant H5 proteins. A) mutant H5N1_2.3.4 K222Q (QS); B) mutant H5N1_2.3.4 S227R (KR); C) mutant H5N1_2.3.4 K222Q/S227R (QR); D) H5N8 Q222K (KR); E) R227S (QS); F) Q227R/R227S (KS). Proteins were applied to the glycan array as detailed in the legend to Figure 2. Letters in parentheses indicate amino acids at positions 222 and 227. Binding of hemagglutinins is indicated in relative fluorescence units (RFU). Binding is shown to sialylated glycans present in the array in nonfucosylated (glycans 1–9; red bars) and fucosylated (glycans 11–19; blue bars) forms. Glycan numbers indicated on the x-axes correspond to glycan structures shown in Figure 3. H5N1_2.3.4, novel H5N1 virus clade 2.3.4.