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. 2017 Feb;23(2):220–231. doi: 10.3201/eid2302.161072

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Structural models of influenza A virus H5 proteins complexed with 3′SLe^X. A) Clade 1 H5 (H5N1₁ of A/Vietnam/1194/2004) complexed with 3′SLe^X (PDB 3ZNM0 (29). B) H5N1_2.3.4 and C) H5N8 hemagglutinins were modeled into the structure shown in panel A as detailed in Materials and Methods. Key amino acids are indicated and shown in a stick representation. C (gray), O (red), and N (blue) in the side chains are colored. SIA, Gal, GlcNAc, and Fuc moieties of 3′SLe^X are shown in purple, yellow, blue, and red, respectively. Hydrogen bonds are indicated by dotted lines. H5N1_2.3.4, novel H5N1 virus clade 2.3.4; H5N1₁, H5N1 virus clade 1.