Table 1.

Echocardiographic analysis of K-Ras mutant mice.

Parameter	WT Sham	WT TAC	Kras+/− Sham	Kras+/− TAC
n	8	4	9	5
DSEP WT (mm)	0.80±0.05	0.85±0.06	0.68±0.03	0.79±0.06
LVEDD (mm)	3.69±0.10	4.65±0.22*	3.69±0.10	3.82±0.10†
DPW WT (mm)	1.01±0.05	0.82±0.04*	0.93±0.03	0.89±0.05
SSEP WT (mm)	1.32±0.08	1.16±0.09	1.13±0.05	1.24±0.09
LVESD (mm)	2.37±0.14	3.90±0.26*	2.46±0.16	2.89±0.07†
SPW WT (mm)	1.46±0.07	1.13±0.06*	1.34±0.05	1.21±0.08
LVEF	0.72±0.04	0.41±0.03*	0.70±0.03	0.57±0.02*†
%FS	35.9±3.0	16.2±1.6*	33.9±2.7	24.3±0.9*
BW (g)	27.7±1.3	30.6±0.9	30.5±1.6	32.7±1.5

Data are presented as mean ± S.E.M.

^*p<0.05 versus respective Sham.

^†p<0.05 versus WT TAC.

DSEP WT (diastolic septum wall thickness), LVEDD (left ventricular end diastolic dimension), DPW WT (diastolic posterior wall thickness), SSEP WT (systolic septum wall thickness), LVESD (left ventricular end systolic dimension), SPW WT (systolic posterior wall thickness, LVEF (left ventricular ejection fraction), %FS (fractional shortening), BW (body weight).