Table 2.

Echocardiographic analysis of H-Ras mutant mice.

Parameter	WT Sham	WT TAC	Hras+/− Sham	Hras+/− TAC	Hras−/− Sham	Hras−/− TAC
n	6	7	4	6	6	7
DSEP WT (mm)	1.01±0.18	1.29±0.08	0.76±0.03	0.76±0.06*	0.86±0.03	0.99±0.06
LVEDD (mm)	4.24±0.20	4.19±0.20	4.07±0.15	4.45±0.24	3.98±0.13	4.15±0.12
DPW WT (mm)	0.65±0.06	0.83±0.06	1.03±0.10†	1.01±0.10	0.70±0.02	0.85±0.06
SSEP WT (mm)	1.64±0.10	1.74±0.07	1.40±0.08	1.20±0.08*	1.24±0.05†	1.31±0.10*
LVESD (mm)	2.76±0.10	3.05±0.19	2.64±0.17	3.25±0.21	2.92±0.15	3.35±0.11
SPW WT (mm)	1.03±0.07	1.24±0.06	1.43±0.12	1.44±0.12	0.86±0.04‡	1.04±0.08§
LVEF	0.72±0.02	0.61±0.03	0.72±0.03	0.61±0.03	0.60±0.03	0.47±0.03*§
%FS	34.6±1.7	27.4±2.1	35.2±2.4	27.1±1.7	26.9±2.1	19.1±1.5*§
BW (g)	31.3±0.6	29.4±0.4	28.4±1.8	30.0±1.2	26.6±0.7†	26.8±0.6†

Data are presented as mean ± S.E.M.

^*p<0.05 versus WT TAC.

^†p<0.05 versus WT Sham.

^‡p<0.05 versus Hras^+/− Sham.

^§p<0.05 versus Hras^+/− TAC.

DSEP WT (diastolic septum wall thickness), LVEDD (left ventricular end diastolic dimension), DPW WT (diastolic posterior wall thickness), SSEP WT (systolic septum wall thickness), LVESD (left ventricular end systolic dimension), SPW WT (systolic posterior wall thickness, LVEF (left ventricular ejection fraction), %FS (fractional shortening), BW (body weight).