Table 3.

Echocardiographic analysis of AAV treated H-Ras^−/− mice.

Parameter	WT Sham	WT TAC	KO Sham	KO TAC	KO + GFP Sham	KO + GFP TAC	KO + Akt Sham	KO + Akt TAC
n	6	6	5	9	4	3	6	6
DSEP WT (mm)	1.01±0.06	1.25±0.05	0.92±0.04	0.95±0.09*	0.79±0.02	0.93±0.04*	0.94±0.08	1.11±0.03
LVEDD (mm)	3.27±0.08	4.26±0.19†	3.35±0.08	4.66±0.18†	3.59±0.25	4.78±0.11†	3.33±0.12	4.08±0.14†
DPW WT (mm)	0.91±0.02	1.01±0.08	1.06±0.09	1.09±0.11	0.96±0.12	0.92±0.13	0.99±0.10	0.99±0.06
SSEP WT (mm)	1.66±0.08	1.64±0.11	1.30±0.12	1.29±0.05	1.35±0.11	1.10±0.05*	1.52±0.10	1.42±0.05
LVESD (mm)	1.72±0.11	2.96±0.29†	2.18±0.15	3.86±0.21†	2.33±0.20	4.01±0.16*†	1.90±0.17	2.90±0.15†‡
SPW WT (mm)	1.29±0.09	1.40±0.10	1.29±0.10	1.02±0.01	1.32±0.19	1.06±0.04	1.37±0.05	1.39±0.07
LVEF	0.85±0.02	0.65±0.07†	0.72±0.05	0.40±0.02*†	0.72±0.04	0.41±0.06*†	0.81±0.04	0.64±0.04‡§
%FS	47.5±2.6	31.3±4.7†	35.1±3.4	17.2±1.4†	35.2±3.3	16.1±2.7†	43.5±3.1	29.1±2.3†
BW (g)	24.9±0.4	29.2±0.6†	25.6±0.7	32.5±1.6†	27.0±0.7	28.9±0.6	28.5±1.3	30.4±1.4

Data are presented as mean ± S.E.M.

^*p<0.05 versus WT TAC.

^†p<0.05 versus respective Sham.

^‡p<0.05 versus KO + GFP TAC.

^§p<0.05 versus KO TAC.

DSEP WT (diastolic septum wall thickness), LVEDD (left ventricular end diastolic dimension), DPW WT (diastolic posterior wall thickness), SSEP WT (systolic septum wall thickness), LVESD (left ventricular end systolic dimension), SPW WT (systolic posterior wall thickness, LVEF (left ventricular ejection fraction), %FS (fractional shortening), BW (body weight).