Table 3. Cumulative incidence estimates of cardiovascular risk factors (CVRF) in childhood HCT survivors treated with TBI (n=123).
Outcome | N | Events | 5-year cumulative incidence* (95% CI) | 10-year cumulative incidence* (95% CI) |
---|---|---|---|---|
Elevated blood pressure | 118 | 34 | 14.7 (8.6, 22.4) | 28.8 (19.2, 39.2) |
Elevated glucose | 121 | 47 | 10.5 (5.5, 17.3) | 33.1 (22.4, 44.1) |
Low HDL-cholesterol | 116 | 58 | 26.8 (18.8, 35.5) | 52.0 (40.7, 62.2) |
Hypertriglyceridemia | 117 | 77 | 39.2 (29.8, 48.4) | 65.0 (53.8, 74.2) |
Obesity | 123 | 21 | 16.0 (9.9, 23.4) | 18.6 (11.7, 26.7) |
CVRF cluster1 | 123 | 35 | 10.6 (5.6, 17.5) | 28.4 (18.8, 38.7) |
HCT indicates hematopoietic cell transplantation; TBI, total body irradiation; CI, confidence interval; and HDL, high-density lipoprotein.
Cumulative incidence estimates reflect the time since TBI with time zero defined as one year after the date of TBI;
Defined as having 3 or more of the following CVRF: obesity, elevated blood pressure, elevated fasting glucose, low HDL, and elevated triglycerides.